Calprotectin is a highly sensitive biomarker for evaluating inflammation of the gastrointestinal tract. The United States Food and Drug Administration (FDA) 501(K) cleared marker is intended to differentiate Irritable Bowel Syndrome (IBS) from Inflammatory Bowel Disease (IBD). Calprotectin is the non-invasive gold standard for assessment of gastrointestinal inflammation and as such, is a useful clinical tool for identifying patients who warrant further GI evaluation.